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Research Articles

Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin

Authors:

W. R. P. L. I. Wijesooriya ,

University of Kelaniya, LK
About W. R. P. L. I.

Faculty of Medicine

 

Department of Medical Microbiology, Faculty of Medicine, University of Kelaniya

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D. N. Kotsanas,

Monash Health, AU
About D. N.
Monash Infectious Diseases
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T. M. Korman,

Monash Health, AU
About T. M.

Monash Infectious Diseases

 

Department of Medicine, School of Clinical Sciences, Monash University

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M Graham

Monash Health, AU
About M

Monash Infectious Diseases

 

Monash Pathology, Monash Health, Clayton, VIC

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Abstract

Introduction and Objectives: Coagulase-negative staphylococci (CoNS) are relatively low in virulence but some are increasingly recognized as agents of clinically important infections. Glycopeptides are the drugs of choice for treatment of methicillin-resistant CoNS infections. Our aim was to analyse the susceptibility profile of CoNS in our healthcare network from 2010-2012.

 

Methods: All CoNS with susceptibility results were analysed as two groups; teicoplanin-susceptible (Teico-S) and non–susceptible (Teico-NS). Analysis included results of other antistaphylococcal antibiotic susceptibilities, sample type (sterile, non-sterile), species and patient location (intensive care unit (ICU) vs non-ICU).

 

Results: Of the 1510 CoNS isolates with susceptibility results, 109 (7.2%) were non-susceptible to teicoplanin. Teicoplanin non-susceptibility was associated with non-susceptibility to ≥ 3 antistaphylococcal-antibiotics, detected more frequently from sterile samples compared to non-sterile samples and from ICU compared to ward patients. Staphylococcus epidermidis was the most common species recovered and was more likely to be Teico-NS.

 

Conclusions: Teicoplanin non-susceptibility is associated with multi-resistance to ≥3 antistaphylococcal antibiotics. Clinicians should be aware that vancomycin resistance may be selected from Teico-NS strains.

How to Cite: Wijesooriya, W.R.P.L.I. et al., (2017). Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin. Sri Lankan Journal of Infectious Diseases. 7(1), pp.10–17. DOI: http://doi.org/10.4038/sljid.v7i1.8116
Published on 04 May 2017.
Peer Reviewed

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