Research Articles
Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin
Authors:
W. R. P. L. I. Wijesooriya ,
University of Kelaniya, LK
About W. R. P. L. I.
Faculty of Medicine
Department of Medical Microbiology, Faculty of Medicine, University of Kelaniya
D. N. Kotsanas,
Monash Health, AU
About D. N.
Monash Infectious Diseases
T. M. Korman,
Monash Health, AU
About T. M.
Monash Infectious Diseases
Department of Medicine, School of Clinical Sciences, Monash University
M Graham
Monash Health, AU
About M
Monash Infectious Diseases
Monash Pathology, Monash Health, Clayton, VIC
Abstract
Introduction and Objectives: Coagulase-negative staphylococci (CoNS) are relatively low in virulence but some are increasingly recognized as agents of clinically important infections. Glycopeptides are the drugs of choice for treatment of methicillin-resistant CoNS infections. Our aim was to analyse the susceptibility profile of CoNS in our healthcare network from 2010-2012.
Methods: All CoNS with susceptibility results were analysed as two groups; teicoplanin-susceptible (Teico-S) and non–susceptible (Teico-NS). Analysis included results of other antistaphylococcal antibiotic susceptibilities, sample type (sterile, non-sterile), species and patient location (intensive care unit (ICU) vs non-ICU).
Results: Of the 1510 CoNS isolates with susceptibility results, 109 (7.2%) were non-susceptible to teicoplanin. Teicoplanin non-susceptibility was associated with non-susceptibility to ≥ 3 antistaphylococcal-antibiotics, detected more frequently from sterile samples compared to non-sterile samples and from ICU compared to ward patients. Staphylococcus epidermidis was the most common species recovered and was more likely to be Teico-NS.
Conclusions: Teicoplanin non-susceptibility is associated with multi-resistance to ≥3 antistaphylococcal antibiotics. Clinicians should be aware that vancomycin resistance may be selected from Teico-NS strains.
How to Cite:
Wijesooriya, W.R.P.L.I., Kotsanas, D.N., Korman, T.M. and Graham, M., 2017. Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin. Sri Lankan Journal of Infectious Diseases, 7(1), pp.10–17. DOI: http://doi.org/10.4038/sljid.v7i1.8116
Published on
04 May 2017.
Peer Reviewed
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