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Molecular diagnostics in a tuberculous patient with clinical non response to standard treatment

Authors:

TP Keerthirathne,

National Institute of Fundamental Studies, LK
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DK Weerasekera,

National Institute of Fundamental Studies, LK
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DN Magana-Arachchi ,

National Institute of Fundamental Studies, LK
About DN
Since joining the National Institute of Fundamental Studies in 2004, Dhammika N. Magana-Arachchi has been the principal investigator of the Cell Biology project. She is currently a Senior Research Fellow of the institute, involved with molecular studies related to tuberculosis, non-tuberculous Mycobacteria, cyanobacteria, CKDu and airborne microorganisms.
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NLA Dissanayake

Respiratory and Chest Clinic, District General Hospital, Nuwara-Eliya,, LK
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Abstract

Rapid distinguishing of mycobacterial species and knowledge about their susceptibility is vital for the management of patients with pulmonary disease who are not responding to initial treatment as the mycobacteria have a spectrum of virulence and different susceptibilities to antibiotics. Most biochemical techniques used for species differentiation are laborious and time consuming. Hence molecular techniques are becoming an alternative to existing conventional testing. This study demonstrates the utility of molecular diagnostics for patients with mycobacterial infections who are not responding to initial anti TB therapy.

Keywords: : NTM TB MDR SYBR Green Real time PCR 
How to Cite: Keerthirathne, T. et al., (2016). Molecular diagnostics in a tuberculous patient with clinical non response to standard treatment. Sri Lankan Journal of Infectious Diseases. 6(2), pp.119–125. DOI: http://doi.org/10.4038/sljid.v6i2.8103
Published on 26 Oct 2016.
Peer Reviewed

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