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Clinical features of hospitalized dengue patients in Sri Lanka from 2004 to 2006

Authors:

W.B. Messer ,

MD PhD Fellow UNC School of Medicine, Dept. of Medicine, Div. of Infectious Diseases CB# 7030 130 Mason Farm Road 2nd Floor Bioinformatics Chapel Hill, NC 27599 Tel: (919) 966-2536 Fax: (919) 966-6714, US
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N Kanakaratne,

MD., MSc., PhD, Former Senior Scientist Genetech Molecular Diagnostics and School of Genetechnology 54, Kitulwatte Road, Colombo 8, LK
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V Thevanesam,

Department of Microbiology Faculty of Medicine University of Peradeniya, LK
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G Ranawaka,

BSc, DIC, PhD Professor in Zoology Department of Zoology Faculty of Natural Sciences Open University of Sri Lanka Tel: 011-2881455 Fax: 011-2806577, LK
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A Shahani,

Former Consultant Microbiologist at Apollo Hospital, Sri Lanka, SG
About A

250  Lorong Chuan, #22-02 Chuan Park, Singapore 556748.

Tel: +65 64057159 /  90895722

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A de Silva

MPH, Ph.D. Associate Professor University of North Carolina at Chapel Hill Department of Microbiology and Immunology C.B. # 7290, M.E. Jones Room 720 Chapel Hill, NC 27599, USA. Tel: (919) 843 9964 Fax: (919) 962 8103, US
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Abstract

The recent emergence of dengue hemorrhagic fever (DHF) in Sri Lanka has been well documented. Here, we present the results of clinical and laboratory evaluation of adult and pediatric PCR positive dengue patients who were hospitalized in Sri Lanka during 2004-2006.  Three hundred and fifty seven patients were included in the study.  Sixty five patients were pediatric (aged 0-12) and 292 patients were adult (aged 13-80).  Patients were classified as having dengue fever (DF), dengue fever with hemorrhagic signs (DFHem) and dengue hemorrhagic fever (DHF). Clinical manifestation of disease differed qualitatively between children and adults. Vomiting and flushing were most common in children and arthralgia/myalgia were the most common finding in adults.  Thrombocytopenia was more common in adults than in children.  A subgroup of 185 patients had the infecting serotype identified by PCR. In the pediatric group, three serotypes, DENV2, DENV3, and DENV4 were found.    DENV3 was the most common overall and in all pediatric diagnoses.  DENV3 and DENV2 were encountered in pediatric DHF patients but not out of proportion to their representation in all pediatric patients.   All four serotypes were identified in the adult group, with DENV3 and DENV2 being the most common.  All four serotypes were found in DHF patients, with DENV3 occurring most frequently but not out of proportion to its occurrence in all adult patients. Our findings, combined with other recent reports of DENV in Sri Lanka, should help us better understand the evolving picture of dengue disease in Sri Lanka.

DOI: http://dx.doi.org/10.4038/sljid.v2i1.3004

Sri Lankan Journal of Infectious Diseases Vol.2(1) 2012: 9-18

How to Cite: Messer, W.B. et al., (2012). Clinical features of hospitalized dengue patients in Sri Lanka from 2004 to 2006. Sri Lankan Journal of Infectious Diseases. 2(1), pp.9–18. DOI: http://doi.org/10.4038/sljid.v2i1.3004
Published on 31 Jan 2012.
Peer Reviewed

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