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Pathogenesis of Dengue viral infections

Authors:

Gathsaurie Neelika Malavige ,

Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayawardanapura, LK
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Neluka Fernando,

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, GB
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Graham Ogg

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford and Department of Dermatology, Churchill Hospital, Oxford, GB
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Abstract

Dengue viral infections are one of the most important mosquito borne viral infections in the world. There are four dengue virus serotypes (DEN1-4) which are closely related. Initial infection with a particular serotype is known as primary infection, which is usually asymptomatic or results in mild disease manifestations. Although cross reactive T cells and cross reactive antibodies have been shown to contribute to disease pathogenesis, these mechanisms alone do not explain the immunopathological mechanisms leading to severe disease. However, studies have suggested that immunopathological, host genetic and viral factors all contribute to the occurrence of severe disease. Therefore, it is important to further investigate the quality of dengue specific immune responses in patients with acute severe and asymptomatic dengue infection, to determine the immune correlates of severe clinical disease and protection.

DOI: http://dx.doi.org/10.4038/sljid.v1i1.2987

Sri Lankan Journal of Infectious Diseases Vol.1(1) 2011: 2-8

How to Cite: Malavige, G.N., Fernando, N. & Ogg, G., (2011). Pathogenesis of Dengue viral infections. Sri Lankan Journal of Infectious Diseases. 1(1), pp.2–8. DOI: http://doi.org/10.4038/sljid.v1i1.2987
Published on 28 Jul 2011.
Peer Reviewed

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