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    Case Reports

    Disseminated Fusarium infection in an immunocompromised patient Successful outcome with combined antifungal therapy

    Authors:

    P.G.R.U.M. Welagedara ,

    Medical Research Institute, Colombo 08, LK
    About P.G.R.U.M.
    Department of Mycology
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    U. A. B. P. Somawardana,

    Apeksha Hospital, Maharagama, LK
    About U. A. B. P.
    Department of Haemato-Oncology and Stem Cell Transplantation
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    N. P. Madarasinga,

    Apeksha Hospital, Maharagama, LK
    About N. P.
    Department of Dermatology
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    M. A. N. Manchanayaka,

    Apeksha Hospital, Maharagama, LK
    About M. A. N.
    Department of Microbiology
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    C. N. Wijesinghe,

    Apeksha Hospital, Maharagama, LK
    About C. N.
    Department of Microbiology
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    G. D. I. Premathilaka,

    Medical Research Institute, Colombo 8, LK
    About G. D. I.
    Department of Mycology
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    P. G. R. I. S. Welagedara,

    Medical Research Institute, Colombo 8, LK
    About P. G. R. I. S.
    Department of Mycology
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    L. S. M. Sigera,

    Medical Research Institute, Colombo 8, LK
    About L. S. M.
    Department of Mycology
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    S. P. Gunasekera,

    Apeksha Hospital, Maharagama, LK
    About S. P.
    ,Department of Microbiology
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    P. I. Jayasekera

    Medical Research Institute, Colombo 8, LK
    About P. I.
    Department of Mycology
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    Abstract

    Fusarium species are plant pathogens which exist ubiquitously in the environment. While they can cause superficial and subcutaneous infections in healthy individuals, they can give rise to deep and disseminated infections in immunocompromised patients, particularly in patients with haematological malignancies with a high risk of mortality. This case describes a young male diagnosed with B cell Acute Lymphoblastic Leukaemia (B-ALL) who developed disseminated Fusarium infection with febrile neutropenia following induction chemotherapy. Necrotic skin lesions led to the diagnosis in this patient. Though the patient had a clinical recurrence of infection due to inadequate treatment initially, he was finally completely cured with combined antifungal therapy using amphotericin B and voriconazole.
    Keywords: Fusarium sp., Disseminated, Immunocompromised
    How to Cite: Welagedara, P.G.R.U.M., Somawardana, U.A.B.P., Madarasinga, N.P., Manchanayaka, M.A.N., Wijesinghe, C.N., Premathilaka, G.D.I., Welagedara, P.G.R.I.S., Sigera, L.S.M., Gunasekera, S.P. and Jayasekera, P.I., 2022. Disseminated Fusarium infection in an immunocompromised patient Successful outcome with combined antifungal therapy. Sri Lankan Journal of Infectious Diseases, 12(2), pp.E23 1–6. DOI: http://doi.org/10.4038/sljid.v12i2.8477
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    Published on 26 Jul 2022.
    Peer Reviewed
      CC BY 4.0

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