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Rare cause of sepsis in an immunocompromised child with acute lymphocytic leukaemia - A Case Report

Authors:

H Thabrew ,

Faculty of Medicine, University of Ruhuna, LK
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LSM Sigera,

Medical Research Institute, LK
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MN Jayawardena,

Medical Research Institute, Colombo 8, LK
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J Galappaththi,

Apeksha Hospital, Maharagama, LK
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P Egodawela,

Apeksha Hospital, Maharagama, LK
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SP Gunasekera,

Apeksha Hospital, Maharagama, LK
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DS Gunasekera,

Apeksha Hospital, Maharagama, LK
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PI Jayasekera

Medial Research Institute, Colombo 8, LK
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Abstract

Haematological malignancies are at a high risk of fungal infection and subsequent high mortality. A patient with a relapsed acute lymphocytic leukaemia (ALL) and a rare fungal infection is presented.

 

A four-year-old patient with ALL relapsed after 3 years of remission. He presented with a papular, erythematous rash mainly on the limbs and trunk, accompanied with high intermittent fever which did not respond to broad spectrum antibiotics.

 

Histopathological examination of a skin biopsy revealed yeast cells. Trichosporon species was isolated on culture. Voriconazole was started according to sensitivity test results and a brief response was demonstrated. Clinical deterioration was seen with worsening of the underlying malignancy. Amphotericin B was added with poor response. Unfortunately, he succumbed to his disease process without recovery from fever, skin rash or the malignancy.

 

Trichosporon species is a rare infection even in patients with haematological malignancies. Recovery from neutropenia is an important prognostic factor in the treatment of trichosporonosis.

How to Cite: Thabrew, H., Sigera, L., Jayawardena, M., Galappaththi, J., Egodawela, P., Gunasekera, S., Gunasekera, D. and Jayasekera, P., 2022. Rare cause of sepsis in an immunocompromised child with acute lymphocytic leukaemia - A Case Report. Sri Lankan Journal of Infectious Diseases, 12(1), pp.E12 1–5. DOI: http://doi.org/10.4038/sljid.v12i1.8466
Published on 29 Apr 2022.
Peer Reviewed

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